Florian Barré, TargetCaRe ESR and PhD student at M4I, has been awarded and received conference fund by the Dutch Society for Mass Spectrometry (NVMS).


The work submitted was based on his recent work on “MALDI-2 improves sensitivity of mass spectrometry imaging of pharmaceutical compounds in biological tissues”.


“Drug imaging is one of the key applications of mass spectrometry imaging (MSI) and enables monitoring drug metabolism and pharmacokinetics (DMPK), but also mapping, and quantification of pharmaceuticals and their metabolites. However, some compounds are not easily ionized with matrix assisted laser desorption/ionization (MALDI), limiting the capabilities of MALDI-MSI for pharmacological applications. Using a wavelength-tunable laser, we have optimized the recently described method of MALDI-2 MSI to initiate secondary gas-phase MALDI ionization processes through laser-induced post-ionization. In this work we demonstrate for the first time the utility of laser-induced post-ionization to dramatically improve the sensitivity of MALDI-based MSI for a suite of drugs and metabolites from a variety of different tissues.”


The submitted application was rated as an excellent scientific quality and will allow Florian to present his work to the American Society of Mass Spectrometry which is the biggest conference for mass spectrometists thank to a conference fund of 1000 euros.

It is also offering a chance to Florian to present this work during the next NVMS conference in the Netherlands.