Project Description

About the project of Du Jie

My project focuses on anti-inflammation research in intervertebral disc(IVD). Nanoparticles (called Nano-Ghosts, Ngs), from mesenchymal stem cells (MSCs), have already been found to specifically target cancer cells. The project aims to investigate the ability of Ngs for specific target of inflamed nucleus pulposus cells (NPCs) and its anti-inflammation effect in inflammatory NPCs model. After then bovine tail IVD organ culture system will be used to verify the effect in situ. Additionally, we will try to reveal the molecular mechanism of its targeting ability and the signal pathway of anti-inflammation effect.