Project Description

About the project of Sonja

My project focuses on regenerative processes in the intervertebral disc (IVD). To investigate these processes, I will first isolate the Nucleus pulposus (NP) cells of a bovine tail IVD and test different regenerative factors in vitro. After the in vitrotest I will use a bovine whole IVD organ culture system in a Bioreactor. After an inflammatory and degenerative environment is created I will inject regenerative factors which are encapsulated in Nanocarriers into the bovine IVD organ culture system. Nanocarriers are particles made of either mesenchymal stem cells (MSCs) or synthesized polymers which can be loaded with drugs. After the successful in vitro testing with bovine cells and organ cultures, the drug-loaded Nanocarriers will be tested in vitroin human IVD culture followed by injection in rat tails as an in vivomodel.